Document 3129
 DOCN  M94A3129
 TI    Natural history of HIV-1 & HIV-2 in cohort of W. African females.
 DT    9412
 AU    Marlink R; Traore I; Thior I; Ndoye I; Essex M; Mboup S; Kanki P;
       Harvard AIDS Institute, Harvard School of Public Health,; Cambridge, MA
       02138.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):147 (abstract no. PB0015). Unique
       Identifier : AIDSLINE ICA10/94369446
 AB    OBJECTIVE: A large cohort of female sex workers has been followed since
       1985 in Dakar, Senegal, to determine the clinical and immunologic
       outcome of HIV-1 and HIV-2 disease. METHODS: Women enrolling in an
       outpatient clinic in Dakar were screened for HIV status after informed
       consent. Prevalent seropositives and known seroconverters, along with a
       stratified seronegative group, were asked to enroll in a clinical
       follow-up study if asymptomatic. RESULTS: Incidence of AIDS according to
       person-years observed (PYO): TABULAR DATA, SEE ABSTRACT VOLUME.
       Kaplanmeir analysis shows that the HIV-2 seroprevalent and
       seroconverters have a significantly longer disease-free time to AIDS or
       CDCIV disease than the HIV-1 seroprevalent or seroconverters
       (Wilcoxon-Gehantest, p < .05). DISCUSSION AND CONCLUSIONS: The rate of
       disease development with HIV-2 is significantly less than that of HIV-1
       in the same region and population. This difference in clinical latency
       has important implications for the individual patient and modeling the
       epidemic for this area.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Comparative Study
       Female  Human  HIV Seropositivity/*EPIDEMIOLOGY  *HIV Seroprevalence
       *HIV-1  *HIV-2  Incidence  Prevalence  Prostitution
       Senegal/EPIDEMIOLOGY  Survival Analysis  *Women  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).